Prozac has a greater affinity for the reuptake trasnporter than MDMA and serotonin both. Most people on Prozac don't feel much when they take ecstasy, because the ecstasy cannot get into the serotonin axon terminal in order to release the serotonin. The ecstasy does cause some dopamine release, as well as norepinephrine, so the user will feel a little something. But the primary effects will be largely inhibited.

Of course, this depends on how much Prozac the person is on, and how big of a dose of MDMA the person takes. Someone on a low dose of Prozac (10mg) will feel more effect than someone on a high dose (40mg). Someone who takes a low dose of MDMA (60mg) will feel less than someone who takes a high dose (150mg).

Now let's look at some other stuff . . .